Pharmacological effects:
Semisynthetic antibiotic broad-spectrum tetracycline group. Have bacteriostatic operating activity.
Is active against gram-positive microorganisms:
Aerobic kokkov-Staphylococcus spp. (including productive producing), Streptococcus spp., including Streptococcus pneumoniae.
Aerobic bacteria Pseudomonas, Bacillus anthracis; aerobic non-spore forming bacteria, Listeria monocytogenes; anaerobic bacteria-Clostridium Pseudomonas spp.
It is also against gram-negative microorganisms:
Aerobic kokkov-Neisseria gonorrhoeae.
Aerobic bacteria, Escherichia coli, Shigella spp., Salmonella spp. and Enterobacter spp., Klebsiella spp., Bordetella pertussis.
The drug is active on Rickettsia spp., Treponema spp. and Mycoplasma spp. and Chlamydia spp.
To the drug resistant Pseudomonas aeruginosa, Proteus spp, Serratia spp., most strains of Bacteroides fragilis.

Pharmacokinetics:
After oral doxycycline almost completely absorbed from the GASTROINTESTINAL TRACT. Food does not affect the absorption of the drug. Maximum plasma concentration of Doxycycline is 2 hours after ingestion. Binding to proteins in plasma-80-95%. Elimination half-life ranges from 15 to 25 hours of doxycycline appears with faeces.

How to apply:
Inside:
After the meal. The patient must drink enough liquid medicine that thus diminished the possibility of irritation of the digestive canal. Daily dose should be taken immediately or split split dose every 12 hours:
It is recommended for most infections in 1-day treatment of 200 mg of the drug. In the following days on 100-200 mg/day depending on the severity of the disease. Infection caused by chlamydia, ureaplazmoj, mikoplazmoj and effectively treat a standard dose of doxycycline for 10-14 days.
Perhaps a combination of doxycycline 100 mg twice/day with klindamicinom or gentamicin (according to).
For more serious infections (especially in chronic infections of the urethra tract) recommended drug 200 mg per day for the cure.
In pelvic inflammatory diseases in acute stage appoint 100 mg 2 times/day for men-100 mg 2 times/day or 300 mg once.
For prophylaxis of infection after medical abortion-100 mg orally 1 h to abortion and 200 mg in through 30 mines after.
When the primary and secondary sifilise is assigned to a daily dose of 300 mg for at least 10 days.
For children over 8 years old and weighing more than 50 kg daily dose is 1-day treatment of 4 mg/kg, in the following days-2-4 mg/kg/day depending on the severity of clinical disease.
If gonorrhoea 100 mg 2 times/day for 2-4 days. Men suffering from gonorejnym-specific urethritis, effectively treat a single dose of 300 mg of doxycycline. If the agent is more sustainable, men should take 200 mg of the drug for four days, while women 200 mg preparation for 5 days.
When acne 50 mg/day; duration of treatment depends on the effectiveness of the drug, it is usually 6-12 weeks.
In the treatment of patients with renal insufficiency safely apply the usual dose of doxycycline.